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UCSF

Honoring Mesothelioma Awareness Day 2014 by Supporting Medical Research

mesothelioma awareness day 2014Mesothelioma Awareness Day 2014 is September 26. But here at Kazan Law, in a way every day is Mesothelioma Awareness Day. Because our work in asbestos litigation brings us close to those whose lives are forever impacted by mesothelioma, we seek not only justice for mesothelioma victims and their families, but also advances in mesothelioma medical research. Through our firm and our firm’s foundation, we help support mesothelioma research at leading medical facilities all over the world. But we place special emphasis on two here in the Bay Area: the University of California San Francisco (UCSF) and Stanford University. Not only are they top notch, they also have helped care for many of our clients.

Like pieces of a jigsaw puzzle, scientific medical research involves finding many small intricate pieces that in the end will fit together to solve the puzzle. We are proud to support scientists in trying to fit together all those parts on a microbiological level to advance knowledge about mesothelioma.

Here are ten recently published research papers where our foundation’s support is noted in the acknowledgements section:

1.The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma

Researchers: Tong Li, Sheng-Cai Hou, Jian-Hua Mao, et al.

Research Institution: The University of California San Francisco

Publication: Journal of Clinical Pathology   Citation: J Clin Pathol 2012 65: 855-858

2.Cul4A is an oncogene in malignant pleural mesothelioma

Researchers: Ming-Szu Hung, Jian-Hua Mao, Zhidong Xu, Cheng-Ta Yang, Jau-Song Yu, Chansonette Harvard, Yu-Ching Lin, Dawn Therese Bravo, David M. Jablons, Liang You

 

Research Institution: University of California San Francisco

Publication: Journal of Cell Molecular Medicine   Citation: J. Cell. Mol. Med. Vol 15, No 2, 2011 pp. 350-358

3.Gli as a Novel Therapeutic Target in Malignant Pleural Mesothelioma

Researchers: Hui Li , Natalie Lui , Tiffany Cheng , Hsin-Hui K. Tseng , Dongsheng Yue, Etienne Giroux-Leprieur, \\

Research Institution: The University of California San Francisco

Publication: The Public Library of Science (PLOS) Citation: PLOS ONE | www.plosone.org 1 March 2013 | Volume 8 | Issue 3 | e57346

4.The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma

Researchers: Etienne Giroux Leprieur, Tomomi Hirata, Minli Mo, Zhao Chen, Junichi Okamoto, Genevieve Clement, Hui Li, Marie Wislez, David M. Jablons, Biao He

Research Institution: The University of California San Francisco

Publication: Lung Cancer Journal   Citation: Lung Cancer (2014), http://dx.doi.org/10.1016/j.lungcan.2014.06.018

5.Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest

Researchers: Iwao Mikami, Fang Zhang1, Tomomi Hirata, Junichi Okamoto, Kiyoshi Koizumi, Kazuo Shimizu, David Jablons and Biao He

Research Institution: The University of California San Francisco

Publication: Oncology Reports   Citation: Oncology Reports 24: 1677-1681, 2010

6.SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma

Researchers: Yi Zhang, Jianxing He, Fang Zhang, Hui Li, Dongsheng Yue, Changli Wang, David M Jablons, Biao He and Natalie Lui

Research Institution: The University of California San Francisco

Publication: Journal of Experimental & Clinical Cancer Research Citation: Journal of Experimental & Clinical Cancer Research 2013, 32:7 http://www.jeccr.com/content/32/1/7

7.The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma

Researchers: Tong Li, Hui Li, Yucheng Wang,Chansonette Harvard, Jia-Li Tan, Alfred Au,7 Zhidong Xu, David M Jablons and Liang You

Research Institution: The University of California San Francisco

Publication: Journal of Pathology  Citation: J Pathol 2011; 223: 519–530

8.Targeting Gli transcription activation by small molecule suppresses tumor growth

Researchers: G. Bosco-Clement, F. Zhang, Z .Chen, H-M Zhou, H. Li, I. Mikami, Hirata, A. Yagui-Beltran, N Lu, H.T. Do

Research Institution: The University of California San Francisco

Publication: Oncogene   Citation: Oncogene (2014) 33, 2087–2097

9.Transgenic Mice for Cre-Inducible Overexpression of the Cul4A Gene

Researchers: Tong Li,Ming-Szu Hung,Yucheng Wang,Jian-Hua Mao, Jia-Li Tan,Kenneth Jahan, Hannah Roos,Zhidong Xu, David M. Jablons and Liang You

Research Institution: The University of California San Francisco

Publication: Genesis: The Journal of Genetics and Development     Citation: genesis 49:134–141 (2011)

10.miR-1 Induces Growth Arrest and Apoptosis in Malignant Mesothelioma

Researchers: Yue Xu , PhD ; Ming Zheng , PhD ; Robert E. Merritt , MD ; Joseph B. Shrager , MD ; Heather A. Wakelee , MD ; Robert A. Kratzke , MD ; and Chuong D. Hoang , MD

Research Institution: Stanford University

Publication: Chest   Citation: Chest 2013; 144(5):1632–1643

Major New Mesothelioma Technology Celebrated at UCSF

From left, Vikki Friedman, Sr. Sales Representative Life Technologies Inc., Dr. Graham Scott, Director Market Development Life Technologies Inc., Mark Gardner, VP and GM Advanced Genomic Systems, Steven Kazan, Founding, Senior and Managing Principal Kazan Law, David M. Jablons, M.D. FACS Professor and Chief Thoracic Surgery UCSF Department of Surgery. Photo credit: James Hall Photography

I was honored last week to speak at an intimate reception which celebrated the inauguration of a major collaboration between global biotechnology company Life Technologies Inc. and the Thoracic Oncology Laboratory at the University of California in San Francisco. Founded in 1995 by thoracic surgeon David M. Jablons, MD and thoracic oncologist Thierry Jahan, MD, UCSF’s Thoracic Oncology Program has been at the forefront of groundbreaking laboratory research, innovative clinical trials, and compassionate, expert care for patients with mesothelioma and other thoracic malignancies.

This event marked the official dedication of 5500 Series SOLiD™ Sequencers, a machine which will drill down on the molecular underpinnings on mesothelioma, lung cancer and other thoracic malignancies.  Efforts to bring this technology to UCSF were greatly helped by the generosity of our clients, mesothelioma victim Gordon Bankhead and his wife, Emily who donated $100,000 towards the purchase of the $750,000 machine. Mr. and Mrs. Bankhead were also invited to attend the reception, but sadly could not because of his illness .

We see these kinds of philanthropic partnerships as essential to laying the foundation for innovative methods of discovery, which will be critical in helping to discover a cure for mesothelioma.

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